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Levitra is a drug used for the treatment of erectile function.

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Release form and composition of the dosage form: tablets-Levitra, round, biconvex, film-coated with a rough surface, from pale orange to greyish-orange color, engraved, printed embossing method-“5”, “10” or “20” on one side and a proprietary bajerovskim Cross (1 or 4 tablets in a blister, in a cardboard bundle for 1 blister). The active ingredient is vardenafil (hydrochloride trihydrate), 1 tablet embossed with “5”, “10” or “20” respectively 5, 10 or 20 mg. Additional ingredients: other ingredients: colloidal silicon dioxide, anhydrous, crospovidone, microcrystalline cellulose, magnesium stearate; Shell: titanium dioxide, iron oxide red, MACROGOL 400, iron oxide yellow, polymer. Indications for erectile dysfunction (inability to achieve and maintain an erection necessary for sexual intercourse).



Levitra should not be used in the presence of concomitant cardiovascular diseases: congestive heart failure, unstable angina and others. The tool is not intended for use in women, children and adolescents under the age of 18 years, as well as with hypersensitivity to any of the components. Not recommended reception preparation (due to lack of safety data) under the following conditions: kidney failure in end stage, requiring dialysis; Severe violations of the liver; Hypotension-sistolicescoe pressure alone below 90 mm Hg (Hg); Hereditary degenerative retinal diseases (such as Retinitis Pigmentosa); Myocardial infarction or stroke, migrated over the past six months. Extreme caution should be taken in patients with medication: anatomical deformation of the penis (the cavernous fibrosis, warp, Peyronie’s disease); innate elongation QT interval; disease predisposing to priapizmu (sickle-cell anemia, leukemia, multiple myeloma); exacerbation of ulcers; aortic stenosis and idiopathic gipertroficski subaortalny stenoses; the propensity to bleeding.


Usage and dosage

Take pills inside, regardless of meals. Initial dose is usually 10 mg, use of the drug is valid from 25-60 minutes up to 4-5 hours before sexual contact (the tool’s efficiency remains at the same level). The recommended maximum frequency reception-1 times per day, depending on the portable tools and therapeutic effect dose can be increased to 20 mg or decreased to 5 mg per day. The maximum dose is 20 mg per day, in order to achieve an adequate response to therapy requires a sufficient level of sexual stimulation. The elderly or with slightly expressed liver failure correction mode is not required. Moderate hepatic insufficiency reviews take 5 mg per day with further possible increase to 10 mg (depending on the acceptability and effectiveness of treatment). Minor or moderate violations of kidney activity is not necessary in correction mode.


Side effects

Central nervous system (CNS): very often-headache; often, dizziness; infrequently-drowsiness, dizestezii, parestesia; seldom-anxiety, amnesia fainting, convulsions; Immune system: seldom-angioedema, allergic swelling; rare allergic reactions; Respiratory system: often-rhinitis, nasal swelling, rinorea; infrequently-stuffy sinuses, shortness of breath; Cardiovascular system: often-vasodilation; infrequently-tachycardia, palpitation; seldom-gipotenzia, myocardial infarction, angina, jeludockove tahiaritmii; Digestive system: often, dyspepsia; seldom-pain in the abdomen, diarrhoea, dry mouth, nausea, gastritis, gastroesophageal reflux disease, increasing transaminaz; The senses: infrequently-disturbed color perception, kongyunctiv hyperemia eyeball, fotofobia, the sensation of pain in the eyes, blurred vision, Vertigo, tinnitus; seldom-raising vnutriglaznogo pressure; Musculoskeletal System: seldom-increased muscle tone, back pain, increasing the concentration of CPK (CPK), mialgia, convulsions; Reproductive system: seldom-increase the duration of erections, painful erection; seldom-priapism; Dermatological reactions: rarely-swelling of the face, photosensitivity. There have been rare cases of anterior ischemic optic neuropathy (PINZN), which is the cause of Visual impairment, including its enduring loss associated with taking FDÈ5 inhibitors, including levitra. In most cases, this condition has been observed in patients with concomitant risk factors for its development, such as diabetes mellitus, anatomic defect drive nerve membranes, coronary artery disease, Hyperlipidemia, hypertension, smoking. There were also reports of violations (including the temporary or permanent loss of vision), associated with the admission of the drug in time. However, it has not been established whether these violations or PINZN with taking Levitra or available concomitant vascular risk factors, anatomical defects, or other reasons. There were no severe side effects when taking the drug at a dose of 80 or 40 mg 1 time per day for over 4 weeks. At the same time, it is noted that using funds in a dose of 40 mg twice per day experienced lower back pain with no signs of toxic effects on the nervous and muscular system. Such a position is assigned to conduct the standard maintenance therapy (efficiency hemodialysis is unlikely). Special instructions before you start taking the doctor should carefully assess the State of the cardiovascular system, because during sexual activity increases the risk of Cardial complications. Vardenafil has a vasodilating effect that can lead to minor or moderate reduction in blood pressure (BP). Because Levitra is causing elongation QT interval should not prescribe pills while using complications preparations class IA and III, such as procainamide, quinidine, sotalol, amiodaron. Not recommended for combined use with other drugs designed to treat erectile dysfunction, because it has not studied the safety and efficacy of such combinations. Simultaneous use with alpha adrenergic can trigger the development of arterial hypotension, because these drugs have vazodilatiruûŝimi properties. This combination is possible with stable indicators hell on Alpha adrenergic therapy and use of levitra in the minimum dose is 5 mg, while taking medications (except for tamsulosin) should not coincide. In the case of the use of selected dose vardenafiladopustimo treatment of Alpha adrenergic started with optimally low dose, its gradual increase can further reduce the hell. In acute ulcers and susceptibility to bleeding can be appointed only after careful evaluation of the ratio of benefits and risks. The drug has no effect on the duration of bleeding, including in combination with acetylsalicylic acid. Impact on the duration of bleeding while using Levitra and heparin is not known. Vardenafil is not conducive to the improvement of platelet aggregation induced by various drugs. At concentrations above the therapeutic means slightly increases antiplatelet effect of sodium nitroprusside, which is a donor of nitric oxide.

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Prescribed drug interaction

When healthy volunteers in a dose of levitra 10 mg, appointed for 1-24 hours before taking nitroglycerin (sublingual dose of 0.4 mg) there was no amplification gipotenzivnogo actions last. When using vardenafil at a dose of 20 mg for 1-4 hours prior to the use of nitrates (sublingually-0.4 mg) recorded increased gipotenzivnogo effect, but when taken for 12:00 am it has not been observed. Cimetidine (nonspecific inhibitor of cytochrome P450 system isoenzymes) in the dose of 400 mg, taken twice a day, as well as the Maalox (an antacid) when one-time admission does not affect the maximum concentration (Cmax) and bioavailability (AUC) vardenafil (20 mg). ACE inhibitors, acetylsalicylic acid, beta-adrenoblokatora, weak inhibitors of CYP3A4, diuretics and hypoglycemic drugs (sulphonylurea and metformin) do not affect the farmakokinetiku drug. There were no pharmacodynamic and pharmacokinetic interaction (effect on coagulation factors II, VII, X and prothrombin time) with the combination of vardenafil (20 mg) with warfarin (25 mg). When combined with vardenafilom (20 mg) not occurring changes in AUC and Cmax glibenklamida (gliburida dose 3.5 mg). There were no significant pharmacokinetic interaction with a combination of levitra (20 mg) and nifedipine (30 or 60 mg): lying on your back vardenafil leads to an additional reduction in systolic and diastolic HELL on average 5.9 mm Hg. Church. and 5.2 mm Hg. Church. respectively. According to the results of clinical trials does not require compliance with the time interval between alfuzozina and vardenafil. AUC vardenafil (20 mg) does not change while applying with blokatorami gistaminovykh H2-receptor antagonists cimetidine (400 mg 2 times a day) and ranitidine (150 mg 2 times a day). Levitra (20 mg) does not increase gipotenzivne effect of ethanol (0.5 g/kg body weight), pharmacokinetics of Vardenafil is not changed. Combined use of Vardenafil is contraindicated in moderately active or powerful inhibitors of cytochrome P450 3A4 (CYP3A4), such as itraconazole, ketoconazole, indinavir, ritonavir, clarithromycin, erythromycin (because they may decrease its clearance and significantly increase concentration in the blood plasma). Not recommended simultaneous intake of levitra with nitrates or drugs that are the portraits of the nitric oxide (not the influence of vardenafil on gipotenzivne effect of these funds). We hope that our article helped you to read buy levitra, learn much more than you knew and added confidence that can happen to anyone, but always leaving such situations will keep in stock and buy levitra no prescription.

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