Doxycycline is a tetracycline antibiotic that is used to treat a variety of bacterial infections.
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The statement accompanying the drug Doxycycline contains information necessary to acquaint the composition of medicines, his testimony to the use and the correct dosing regime. All warnings concerning the use of doxycycline in treatment also described in detail.
Form, composition, packaging
The drug Doxycycline is a capsule with active ingredient doxycycline hydrochloride at a concentration of 100 milligrams.
Buy drug Doxycycline can be in online pharmacy, where it comes in packs from a dense paper, cardboard, with one or two plates contour packaging, where cells with capsules of 10 pieces each.
Terms and conditions of storage
The preparation should be stored in areas where there is no moisture and sunlight penetrates. Storage temperature of not more than 25 degrees. Shelf life of no more than 4 years. Children access forbidden.
As bacteriostatic antibiotic with a broad spectrum of action of Doxycycline belongs to the Group of semisynthetic tetracycline. His ability to enter inside cells allows him to influence the pathogens that are inside them, inhibiting their protein synthesis and disrupting transport links.
Drug sensitive many grampolaugitionah and gramotricationah microorganisms, as well as intracellular pathogens.
However, there are a number of micro-organisms pathogenic nature with whom Doxycycline cope. Many strains of Escherichia coli, Proteus and fungi.
Intestinal flora is not so pronounced oppressing unlike other antibiotics tetracycline series, besides absorbed more fully and differs in that its therapeutic effect is more enduring. Bacterial activity of the drug is high especially in contrast to tetracycline of natural origin. The drug is able to provide high therapeutic effect that will use smaller doses ten times. Has cross-resistant nature of the other medication tetracycline and penicillin.
The drug Doxycycline offers quite a wide range of activity, which shows to the appointment for the treatment of wide range of diseases infectious-inflammatory nature that caused by those pathogens that are sensitive to the drug in various areas of the body.
Infectious diseases of the respiratory system Disease called pharyngitis, bronchitis, empyema in acute and chronic form by light, bronhopnevmoniej, pneumonia Lobar;
Infectious diseases in the field of ENT Illnesses, called otitis media, sinusitis, tonsillitis;
Infectious diseases of the genitourinary system Disease that is called cystitis, gonorrhoea, pyelonephritis, acute orhièpididimitom, prostatitis, urethritis, èndocervicitom, èndometritom, uretrocistitom, uretrogenital′nym from mycoplasmosis;
Infection ways of deducing the bile and DIGESTIVE TRACT Disease called cholecystitis, diarrhoea “travelers”, holangitom, dysentery, bacillary gastroènterokolitom;
Infectious diseases of the skin and soft tissues When the cramps, wounds, Burns, abscessah, panariciâh infections, Furunculosis;
Different infectious diseases eye infections, malaria, syphilis, yaws, aktinomikoze, iersinioze, cholera, tularemia, legionelleze, dysentery amoebic or bacillary, rikketsioze, Lyme disease, chlamydiosis, tife, spotted fever;
The drug is included in the comprehensive treatment of the following diseases: diagnosis When leptospiroze, peritonitis, trachoma, subacute endocarditis, septic psittakoze, sepsis, osteomyelitis, ornitoze, èrlihioze granulocitarnom, brucelleze, whooping cough.
As a preventive measure postoperative purulent nature of malaria;
Has the drug and some contraindications that must be taken into account when prescribing treatment for the patient. Doxycycline should not berecommended to receive If identified the patient as a hypersensitivity to doxycycline and other drugs tetratziklinova groups; children under 12years of age, especially if they weigh less than 45 kilograms; When laktaznom deficiency; When radiation; If lactase intolerance; renal failure insevere form; malabsorbtion glucose-galaktoznoj; in porfirii.
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The average daily dosage for an adult patient and the child over the age of 12 years (more weight 45 kg) is 200 milligrams per reception the first day (100 mg twice per day) in the coming days to 100 milligrams per day.
Chronic infections of the urinary system
Appoint 200 milligrams per day for the entire period of treatment.
Treatment is recommended, adhering to the following scheme:
In a complicated form of the disease course dose is up to 900 milligrams of doxycycline, which should be distributed on 6 or 7 steps: 1 St admission-300 milligrams, then 5 or 6 equal parts with an interval of taking the drug in six hours.
In acute not complicated uretrite dose course consists of 500 milligram 1 St admission-300 milligrams, then 2 reception for 100 milligrams six hours or 100 milligrams once per day until full recovery for women; for men by 100 milligrams twice a day for a week.
Appoint 300 milligrams per day for ten days.
Does not cause infection of the rectum, cervix, mocheispuskatelland channel
Assigned to 100 milligrams twice a day during the week.
Infection of male genital organs
On 100 milligrams twice per day for a month.
Malaria: prevention and treatment
Resistance to chloroquine treatment on 200 milligrams per day for a week, it is advisable to combine with quinine;
Prophylaxis to 100 mg 1 time per day for 2 days before the trip, every day during the journey and return within a month.
For 200 milligram at the beginning of the trip and then 100 mg daily during the entire period of travel, but not more than 21 days.
On 100 milligrams twice a day for a week;
For prevention of 200 milligrams once a week during your stay in the area with a dysfunctional situation regarding infection and another 200 milligram at the end of the trip.
After medaborta in order to prevent infection
100 milligram per hour prior to the procedure and 200 milligrams in half upon completion.
To 100 milligrams per day from 6 to 12 weeks.
For the adult patient maximum dose per day may be no more than 300 milligrams per 5 days; in the presence of severe infections (gonococcus) isallowed Reception up to 600 milligrams.
To avoid gepatoksii in connection with cumulation of the drug to patients with the presence of severe renal insufficiency daily dose.
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When pregnancy Doxycycline buy online is prohibited. This is due to the fact that the drug penetrates through the placental barrier and threatens normal development of dental and bone tissues of the fetus, as well as the possible fatty infiltration of his liver.
Breastfeed if necessary, treatment should not be Doksiciklinom.
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Doxycycline for children
Doxycycline can be appointed for children exclusively with twelve years of age, provided that the child’s weight exceeds the weight figures 45 kilograms. Major contraindication to childhood patients serves as a conversion of the active substance of the preparation with Ca ions to insoluble complex that is capable to deposition of dentin in the tooth enamel of the tooth, also in the tissues of the bones of the child.
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Interactions with medications
The combination of Doxycycline with antacids, sodium bicarbonate, iron or laxatives can reduce its absorption. Therefore, their reception it isrecommended that you divide the time interval that is not less than three hours.
Because its effects Doxycycline inhibits the intestinal microflora, prothrombin index decreases. This circumstance requires the correct dose ofindirect anticoagulants if necessary for their application.
The combination of Doxycycline with others
The combination of Doxycycline with other antibiotics cephalosporin or penicillin group decline efficacy.
Oral contraceptives may lose its reliability, and you can also increase the occurrence of breakthrough bleeding when you combine the antibiotic with a èstrogenosoderžaŝimi contraceptives.
Doxycycline concentration in plasma can significantly decrease because of accelerating his metabolism by combining with stimpacks mikrosomalnogo oxidation: phenytoin, carbamazepine, ethanol, barbiturates, rifampicin and others.
Methoxyflurane when combined with Doksiciklinom can lead to the development of renal failure acute nature that threatens to fatal.
Intracranial pressure increases when the interaction of doxycycline and retinol.
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Doxycycline has a large list of side effects that must be taken into account when appointing drug therapy and its application. Possible side effects can affect many organs and systems of the body.
Nervous system the appearance of increasing pressure vnutricerepnogo benign character that manifests itself in reduced appetite, swelling drive nerve of vision, headaches. Can also develop impact on CNS toxicity that will be expressed Vertigo and state fragility.
Metabolism the development of anorexia.
Vestibular apparatus and hearing the possible emergence of tinnitus.
Vision can be blurred, and can also increase intracranial pressure that will lead to the development of diplopia and scotomas.
Digestive system possible development of enterocolitis due proliferation resistant staph strains, the emergence of bouts of toxicosis, psevdomembranoznogo colitis, constipation or diarrhea, pain in the abdomen, the formation of ulcers in the stomach and duodenum, Glossitis, gastritis, Erosive Esophagitis, or dysphagia.
Allergy reactions Development of Stevens-Johnson Syndrome, makulopapuleznoj rashes, anaphylaxis, skin itching, anaphylactic shock, hyperemia skin, swelling angioneuroticeski anaphylactoidnykh reactions, urticaria, Lupus Erythematosus drug, èritematoznoj rashes, dermatitis exfoliativogo.
Cardio-vascular system the emergence of mnogoformna eritema, pericarditis, tachycardia, falling blood pressure.
Hemopoiesis Development of hemolytic anemia, reduced prothrombin index, trombozitopenia, èozinofilii, leukopenia, neutropenia.
Hepatobiliary system Demonstration of functionality of the liver, Cholestasis, may rise the level transaminaz liver, hepatitis, autoimmune.
Musculo-skeletal apparatus Manifestations mialgii, arthralgia.
The functionality of the kidneys and urinary ways residual level of urea nitrogen can be upgraded.
Different Development of epidermal nekroliza toxic, photosensitivity, savorotocnuu-like syndrome disease, superinfection, dysbiosis, alteration of tooth enamel in color, candidiasis, inflammation in the area of the anus and genitals.
Usually, symptoms of overdose are those patients who suffer from impaired liver functionality, especially when the dosage is overstated. Neurotoxic reactions occurs in nature in the form of attacks toxicosis, vomitoxin process dizziness until human consciousness or convulsions that can serve as a consequence of the increase in intracranial pressure.
Treat overdosing doksiciklinom should be the lifting of the preparation. The patient should rinse stomach with subsequent appointment activated charcoal. Shown symptomatic therapy. Recommended reception antatsidov and magnesium sulfate to neutralize further absorption of the antibiotic.
There is no specific antidote. A kidney dialysis or peritoneal dialysis will have no effect.
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